​​Meta Analytical​

INDUSTRIAL AND ENVIRONMENTAL SERVICES SECTORS


Deliverable: Identification and quantification of trace contaminants in air, water, soil/sediments, organisms (tissues/biofluids)  


Instrumentation and Target Analytes:


ICP-MS

  • Metals (Al, As, Cr, Co, Cd, Cu, Fe, Hg, Mn, Ni, Pb, Se, V, Zn...)
  • Metalic Nanoparticles (n-Ag, n-TiO2, n-ZnO)
  • Other Engineered Nanoparticles of Concern


GC-EI-MS and GC-EI-MS/MS:

  • Polychlorinated dibenzo-p-dioxins (PCDDs), Polychlorinated dibenzofurans (PCDFs), Polychlorinated biphenyls (PCBs) 
  • Polycyclic Aromatic Hydrocarbons (PAHs)
  • Halogenated Flame Retardants (HFRs) 
  • Current Use Pesticides (CUPs)
  • Benzene-Tolune-Ethylbenzenes-Xylenes (BTEX)
  • Fatty Acid Methyl Esters (FAMES) for Biofuel Characterization and Food Quality Assessments
  • Other Emerging Contaminants of Concern


LC-ESI-MS/MS

  • Poly- and Per-fluoroalykyl Substances (PFASs) 
  • Pharmaceutically Active Compounds (over 60 targets) including antibiotics, lipid regulators, stimulants, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), anti epileptics, antihistamines, anticoagulants, synthetic estrogens, beta blockers, selective estrogen receptor modulators (SERMs).
  • Home and Personal Care Products (HPCPs)
  • Estrogens and Endocrine Disrupting Chemicals (EDCs) 
  • Naphthenic Acids for Characterization of Industrial Process Water
  • Other Emerging Contaminants of Concern


BIOTECHNOLOGY AND PUBLIC HEALTH SECTORS


Deliverable: Identification and quantification of small molecule metabolites and proteins in biological matrices (breath, saliva, urine, plasma). Provide multivariate statistical analyses (PCA, PLS-DA, Hierarchical Clustering) to assess profile pattern changes. 


Instrumentation and Target Analytes:


GC-EI-QTOFMS and LC-ESI-QTOFMS based metabolome profiling (targeted and untargeted analyses)


  • Common metabolites monitored for profile changes: 2-hydroxybutyrate, 3-hydroxybutyrate, 3-methyl, 2-hydroxybutyrate, valine, leucine, urea, proline, glycerinate, glycine, serine, threonine, methionine, creatinine, aspartate, phenylalanine, glutamate, laureate, glycerol phosphate isomer, citrate, glucose, lysine, tyrosine, palmitate, myo-inositol, urate, tryptophan, linoleate, oleate, stearate, cystine, cholesterol, D-mannose, D-glucose, maltose, dehydroascorbic acid, glycerol-1 phosphate, 3-phosphoglycerate, oxalic acid, lactic acid, succinic acid, alanine, mimosine, isoleucine, N-acetyl-L-aspartic acid.



Deliverable: Identification and quantification of proteins in biological matrices (urine, plasma, cells). Provide multivariate statistical analyses (PCA, PLS-DA, Hierarchical Clustering) to assess profile pattern changes. 

Instrumentation and Target Analytes: LC-ESI-QTOFMS based proteome profiling (targeted and untargeted analyses). 


  • Proteome profiling methods utilze “bottom-up”, gel-free approaches such as ICAT and MudPIT and Isobaric Tag for Relative and Absolute Quantitation (iTRAQ). Quadrupole time of flight (QTOF) mass spectrometry, which incorporates multiple reaction monitoring (MRM) for selective targeted analysis of peptide precursor fragment ions.  



Deliverable: Identification and quantification cannabinoids and metabolites for medical and forensic applications.

Instrumentation and Target Analytes:

GC-EI-MS/MS and GC-EI-QTOFMS


  • Cannabinol (CBN)
  • Cannabidiol (CBD)
  • (−)-Δ9-(trans)--Tetrahydrocannabinol (THC)
  • (−)-Δ9-(trans)-Tetrahydrocannabinolic acid (THCA)